Biosciences and Bioengineering
About the project: Project: ?Probing the role of extracellular matrix stiffness on exosome secretion, and its influence on cancer invasion?
The focus of this project is to probe the role of extracellular matrix stiffness in modulating exosome secretion, exosome composition, and the effect of these exosomes vis-a-vis cancer progression and cancer invasion.
Essential qualification and experience: Post graduate degree (MSc) with 70% marks in Life sciences, Biotechnology, Zoology or related field from a recognized university.
Candidate must have minimum 6 months? work experience with the knowledge of cell culture techniques and immunological techniques. Candidates with previous experience in exosome isolation and characterisation would be preferred.
*MSc degree having duration of one-year course would not be considered.
Consolidated salary: Rs 18000 to 25000/- (depending upon qualification and experience) + 30% HRA per month
Mode of selection: Written test and/or interview
Junior Research Fellow: (1 Post) Eligibility : M.Sc with NET qualification and 6 months Experience
Salary : Consolidated salary Rs.18000/- pm + 30% HRA
Job Profile : The candidate will fabricate hydrogels, assist in cell culture, exosome isolation and characterisation, data analysis, and also assist in routine lab duties.
Faraday wave instability device for high-concentration droplet generation: Application to aerosol synthesis of drugcontaining nanoparticles
About the project: Recently, a new technology of liquid atomization has been proposed in the literature involving Faraday wave instabilities amplified through Fourier horns. The advantage of this technology lies in the optimization of power and improved control of particle sizes when compared to existing ultrasonic nebulization devices. The application of this technology so far has been limited to pocket based
inhalation devices. The technology appears very attractive for the generation of nanoparticles in general and specifically for the laboratory synthesis of drug nanoparticles for various inhalation or injection based applications. This project envisages the development and scale-up of an atomization device based on the above principle. This device will be integrated with an existing aerosol reactor system for generation of dry nanoparticles of various drug materials.
The initial part of the work involves experiments towards development of a droplet atomization device based on amplifying transducer induced vibrations imparted to a liquid droplet. Subsequent experimental work involves characterization of the droplets produced and integrating the system with an aerosol reactor. The study will also involve setting up of computations involving Faraday waves, to understand and fine tune the processes.
The candidate should have an aptitude for experimental work involving performing multiple trials, carrying out measurements, designing the prototype units for fabrication. He/She must also have interest in modelling and numerical simulations. Background in fluid mechanics and elementary electronics is desirable.
Junior Research Fellow: (1 Post) Eligibility : M.Tech in Mechanical/Chemical/Electrical or Physics
Salary : Consolidated salary Rs.25000/-+ H.R.A(if applicable) p.m.
Job Profile : Use of Function generators, PZT transducers etc. Vibration induced atomisation and characterisation, working with sophisticated instruments like SMPS, high speed camera etc. Trials for optimising design. Numerical simulations, analysis.